国际眼科纵览 ›› 2023, Vol. 47 ›› Issue (3): 264-268.doi: 10.3760/ cma.j.issn.1673-5803.2023.03.012

• 综述 • 上一篇    下一篇

Fuchs综合征发病机制的研究进展

陈子杰1,2  毛禹凯3  刘旭阳2  朱益华4   

  1. 1 厦门大学医学院 361104;2 厦门大学附属厦门眼科中心 361000 ;3 福建医科大学医学技术与工程学院,福州 350122;4 福建医科大学附属第一医院眼科,福州 350122
  • 收稿日期:2022-11-11 出版日期:2023-06-22 发布日期:2023-06-29

Research progress on the pathogenesis of Fuchs syndrome

Chen Zijie1, 2, Mao Yukai3, Liu Xuyang2, Zhu Yihua4   

  1. 1 School of Medicine, Xiamen University, Xiamen 361104, China; 2 Xiamen Eye Center, Xiamen 361000, China; 3 School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, China; 4 Department of Ophthalmology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350122, China
  • Received:2022-11-11 Online:2023-06-22 Published:2023-06-29

摘要: Fuchs综合征是一种慢性非肉芽肿性虹膜睫状体炎,主要特征有角膜后沉浊物、虹膜异色。由于早期炎症反应较轻容易被忽略,后期则会引起危及视力的严重并发症如白内障和青光眼。因此,对于Fuchs综合征的治疗主要是针对并发症的治疗,可以开展超声乳化吸除联合人工晶体植入、小梁切除术或青光眼引流阀手术、使用抗青光眼药等。目前对于Fuchs综合征的病因尚不明确,有作者认为Fuchs综合征是由多种病因共同导致的一组具有相似临床表现的疾病,也有作者认为该病由病毒感染所致,不属于综合征。此外,遗传、免疫及交感神经等也可能与Fuchs综合征有关。(国际眼科纵览,2023, 47:264-268

关键词: Fuchs综合征, 病因学, 发病机制

Abstract: Fuchs uveitis syndrome is a chronic non granulomatous iridocyclitis characterized by posterior corneal opacities  and iris discoloration. Due to the mild inflammatory response in the early stage, it is easy to be ignored, while in the later stage, it can cause serious complications that impair vision, such as cataracts and glaucoma. Therefore, the treatment of Fuchsuveitis syndrome is mainly aimed at the treatment of complications, such as phacoemulsification combined with intraocular lens implantation, trabeculectomy or glaucoma drainage valve surgery, and the use of anti-glaucoma drugs. At present, the etiology of Fuchs uveitis syndrome is not yet clear. Some authors believe that Fuchs uveitis syndrome is a group of diseases with similar clinical manifestations caused by multiple causes, while the others believe that the disease is caused by viral infection and does not belong to the syndrome. In addition, genetics, immunity, and sympathetic nerves may also be related to Fuchs uveitis syndrome. (Int Rev Ophthalmol, 2023, 47: 264-268)

Key words: Fuchs uveitis syndrome, etiology, pathogenesis